6-溴-3,4-亚甲基二氧苯甲醛合成路线 （共 110 条）
参考文献
Fales et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5885,5889
反应条件
sodium methylate; dimethyl sulfoxide T=150°C; 0.0194444 h;
参考文献
Heterocycles, , vol. 31, # 6 p. 1067 - 1076
反应条件
sodium methylate; dimethyl sulfoxide; benzyl alcohol T=150°C; 0.0194444 h;
参考文献
Heterocycles, , vol. 31, # 6 p. 1067 - 1076
反应条件
in dimethyl sulfoxide T=150°C; 0.0194444 h;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 28, # 4 p. 1287 - 1293
反应条件
sodium methylate; dimethyl sulfoxide T=150°C; 0.0194444 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Imakura, Yasuhiro; Okimoto, Kazuto; Gorohata, Chizuru; Kobayashi, Shigeru; Kihara, Masaru; Yamashita, Shinsuke
Heterocycles, 1990 , vol. 31, # 6 p. 1067 - 1076
反应条件
dimethyl sulfoxide T=150°C; 0.0194444 h; other sodium alkoxide - alcohol (or phenol) systems and sodium alkoxide - alcohol - alcohol (or phenol) systems; various temperatures and reaction times; Product distributionMechanism;
参考文献
Imakura, Yasuhiro; Okimoto, Kazuto; Gorohata, Chizuru; Kobayashi, Shigeru; Kihara, Masaru; Yamashita, Shinsuke
Heterocycles, 1990 , vol. 31, # 6 p. 1067 - 1076
→
4375-07-95,8,8a,9-四氢-9-羟基-5-(3,4,5-三甲氧基苯基)-(5R,5aR,8aR,9S)-呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5aH)-酮+
反应条件
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane / 12 h / 0 - 20 °C / |Inert atmosphere 2.1: n-butyllithium / diethyl ether; tetrahydrofuran; hexane / 0.42 h / -78 °C / |Inert atmosphere 2.2: 1.08 h / -78 - 0 °C / |Inert atmosphere 3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 °C / |Inert atmosphere 3.2: 0.5 h / -78 - 0 °C / |Inert atmosphere 4.1: lithium triethylborohydride / tetrahydrofuran; toluene / 0.5 h / -78 °C / |Inert atmosphere 4.2: 12 h / 20 °C / |Inert atmosphere 5.1: potassium carbonate; palladium diacetate; dibenzyl hydrogen phosphate / 1,1-dimethylpropan-1-ol / 50 h / 110 °C / |Inert atmosphere 6.1: trifluoroacetic acid / tetrahydrofuran; water / 27 h / 0 - 25 °C / |Inert atmosphere View Scheme
参考文献
Ting, Chi P.; Maimone, Thomas J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3115 - 3119
Angew. Chem., 2014 , vol. 126, # 12 p. 3179 - 3183,5
参考文献
Jung, Michael E.; Lam, Patrick Yuk-Sun; Mansuri, Muzzamil M.; Speltz, Laurine M.
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1087 - 1105
反应条件
hydroxylamine hydrochloride; sodium acetate; acetic acid T=125°C; 12 h;
参考文献
MYRIAD GENETICS, INC.
Patent: WO2009/65035 A1, 2009 ;
Location in patent: Page/Page column 67 ;
反应条件
copper in N,N-dimethyl-formamide T=170°C;
参考文献
Kobayashi; Mineo; Kihara; Tagashira
Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 9 p. 2191 - 2198
