6-溴-3,4-亚甲基二氧苯甲醛合成路线 （共 110 条）
反应条件
1: p-TsOH / benzene / 15 h / Heating
2: n-BuLi, I2 / hexane; tetrahydrofuran
3: 20percent aq. HCl / methanol; benzene / 16 h
4: 97 percent / NaBH4 / propan-2-ol / 16 h / Heating
5: 87 percent / HCl / acetic acid; CH2Cl2 / 5 h / Ambient temperature
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
1: (iodo-2 trimethoxy-3,4,5 benzyl)-3-butanolide-4, Copper bronze / 0.58 h / 225 °C
2: 69.5 percent / Na / methanol / 1.33 h / Heating
3: 97.5 percent / H2 / 5percent Pd/C / acetic acid / 16 h / 30 °C / 22800 Torr
4: 1.) KOH, 2.) Ca(BH4)2 / 1.) H2O, 2.) ethanol, 10 deg C, 2 h
View Scheme
参考文献
Brown, Eric; Robin, Jean-Pierre; Dhal, Robert
Tetrahedron, 1982 , vol. 38, # 16 p. 2569 - 2580
反应条件
sodium methylate; copper dichloride in N,N-dimethyl-formamide
T=100 - 105°C; 1.5 h;
参考文献
Baratov, N.U.; Vinogradova, V.I.; Yunusov, M.Yu.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 7 p. 1380 - 1381
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 7 p. 1578 - 1579
反应条件
sodium methylate in N,N-dimethyl-formamide
T=100 - 105°C; 1.5 h;
参考文献
Baratov, N.U.; Vinogradova, V.I.; Yunusov, M.Yu.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 7 p. 1380 - 1381
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 7 p. 1578 - 1579
反应条件
copper dichloride in N,N-dimethyl-formamide
T=100 - 105°C; 1.5 h;
参考文献
Baratov, N.U.; Vinogradova, V.I.; Yunusov, M.Yu.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 7 p. 1380 - 1381
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 7 p. 1578 - 1579
反应条件
1: 63 percent / sodium methylate / dimethylformamide / 1.5 h / 100 - 105 °C
2: 75 percent / CuCl2 / dimethylformamide / 1.5 h / 100 - 105 °C
View Scheme
参考文献
Baratov, N.U.; Vinogradova, V.I.; Yunusov, M.Yu.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 7 p. 1380 - 1381
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 7 p. 1578 - 1579
反应条件
1: Oxonereg; / N,N-dimethyl-formamide / 1 h / 20 °C
2: thionyl chloride / diethyl ether / 1 h / 0 - 5 °C
3: ammonium hydroxide / 2 h / 0 - 20 °C
View Scheme
参考文献
Praveen, Chandrasekaran; Dheenkumar; Perumal
Journal of Chemical Sciences, 2013 , vol. 125, # 1 p. 71 - 83
反应条件
N-bromosuccinmide; chloroform
Behandeln der Reaktionsloesung mit Ammoniak;
参考文献
Yamaguchi
Nippon Kagaku Kaishi, 1956 , vol. 77, p. 591,592
Chem.Abstr., 1958 , p. 305
反应条件
in ethanol
2 h; Heating;
参考文献
Gupta, Y. P.; Chawla, Ravinder; Sawal, K. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 7 p. 652 - 654
反应条件
pyridinium p-toluenesulfonate in toluene
5 h; Heating;
参考文献
Paulsen; Stubbe
1983 , vol. No. 4, p. 535 - 556
