6-溴-3,4-亚甲基二氧苯甲醛合成路线 （共 110 条）
反应条件
2: 93 percent / NaBH4 / ethanol / 1.)2 h, 0-5 deg C, 2.) 12 h, 25 deg C
View Scheme
参考文献
Beck, Daniel E.; Agama, Keli; Marchand, Christophe; Chergui, Adel; Pommier, Yves; Cushman, Mark
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1495 - 1512
反应条件
1: With AlCl3, aluminium chloride in dichloromethane
T=20°C;
2: With hydrogenchloride; potassium iodide in tetrahydrofuran
参考文献
Cudaj, Judith; Podlech, Joachim
Synlett, 2012 , # 3 p. 371 - 374
反应条件
1: AlCl3 / CH2Cl2 / 2 h
2: 6N HCl, KI / tetrahydrofuran / Heating
3: K2CO3, KI / ethanol / 18 h / Heating
View Scheme
参考文献
Cudaj, Judith; Podlech, Joachim
Synlett, 2012 , # 3 p. 371 - 374
反应条件
hydrogenchloride; amalgamated zinc; acetic acid; toluene
参考文献
Tomita et al.
Yakugaku Zasshi, 1952 , vol. 72, p. 384,386
Chem.Abstr., 1953 , p. 7453
反应条件
1: aq. NaOH solution
2: benzene; hydrogen chloride
3: ethanol
4: aq.-ethanolic NaOH-solution
View Scheme
参考文献
Naik; Wheeler
Journal of the Chemical Society, 1938 , p. 1780,1782
反应条件
1: Jones reagent
2: SOCl2; DMF / CH2Cl2
View Scheme
参考文献
Grimshaw, James; Hamilton, Robert; Trocha-Grimshaw, Jadwiga
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 229 - 234
反应条件
1: piperidine; pyridine
2: hydrogen bromide; glacial acetic acid / 60 - 70 °C / Behandeln des Reaktionsgemisches mit ueberschuessigem Zinkstaub bei 80grad
View Scheme
参考文献
Haworth; Perkin; Stevens
Journal of the Chemical Society, 1926 , p. 1766
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere
1.2: 0 - 20 °C / |Inert atmosphere
2.1: lithium triethylborohydride / tetrahydrofuran / -78 - 20 °C / |Inert atmosphere
3.1: pyridinium chlorochromate; silica gel / dichloromethane
View Scheme
参考文献
Rochette, Elise M.; Lewis, William; Dossetter, Al G.; Stockman, Robert A.
Chemical Communications, 2013 , vol. 49, # 82 p. 9395 - 9397
反应条件
1.1: PTSA / benzene
2.1: n-BuLi
2.2: I2
3.1: H3O(1+)
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
1: copper-powder / 230 °C
2: sodium borate; methanol / anschliessend Ansaeuern mit wss. Schwefelsaeure
View Scheme
参考文献
Ikeda et al.
Journal of the Chemical Society, 1956 , p. 4749,4757
