2,3-环氧-16-(1-吡咯基)-雄甾-17-酮合成路线 （共 9 条）
反应条件
1: in methanol T=60 - 65°C; 0.333333 - 0.5 h; Heating / reflux; 2: With water in methanol T=65 - 70°C; 0.833333 - 2 h; Heating / reflux; Purification / work up;
参考文献
Mendez, Juana Araceli; De La Mora, Marco A.; Rodriguez, Angel A.; Barragan, Efrain; Herrera, Hugo; Guillen, Alejandro
Patent: US2007/117975 A1, 2007 ;
Location in patent: Page/Page column 11; 18 ;
反应条件
in water; acetonitrile
参考文献
Marvishi Pharmaceutical Co., Ltd.
Patent: US5591735 A1, 1997 ;
反应条件
1: 2α,3α:16α,17α-diepoxy-17β-acetoxy-5α-androstane With sodium hydroxide in methanol; water 0.5 h; Heating / reflux; 2: pyrrolidine in methanol; water T=40°C; 0.25 h; Heating / reflux; Product distribution / selectivity;
参考文献
Mendez, Juana Araceli; De La Mora, Marco A.; Rodriguez, Angel A.; Barragan, Efrain; Herrera, Hugo; Guillen, Alejandro
Patent: US2007/117975 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 2α,3α:16α,17α-diepoxy-17β-acetoxy-5α-androstane With sodium hydroxide in methanol; water T=20°C; 0.5 h; Heating / reflux; 2: pyrrolidine in methanol; water T=40°C; 0.25 h; Heating / reflux; Product distribution / selectivity;
参考文献
Mendez, Juana Araceli; De La Mora, Marco A.; Rodriguez, Angel A.; Barragan, Efrain; Herrera, Hugo; Guillen, Alejandro
Patent: US2007/117975 A1, 2007 ;
Location in patent: Page/Page column 17 ;
反应条件
in methanol; water T=35 - 65°C; 0.5 - 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
Mendez, Juana Araceli; De La Mora, Marco A.; Rodriguez, Angel A.; Barragan, Efrain; Herrera, Hugo; Guillen, Alejandro
Patent: US2007/117975 A1, 2007 ;
Location in patent: Page/Page column 11; 17; 18 ;
反应条件
in dichloromethane; water T=20 - 22°C; 22 h; Product distribution / selectivity;
参考文献
Mendez, Juana Araceli; De La Mora, Marco A.; Rodriguez, Angel A.; Barragan, Efrain; Herrera, Hugo; Guillen, Alejandro
Patent: US2007/117975 A1, 2007 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With sodium tetrahydroborate in methanol T=-10 - 24°C; 3 h; 2: With water in methanol; dichloromethane T=20 - 22°C; 0.166667 h; Product distribution / selectivity;
参考文献
US2007/117975 A1, ;
Page/Page column 11 ;
反应条件
1: With sodium tetrahydroborate in methanol; dichloromethane T=0 - 25°C; 2.66667 h; 2: With water in methanol T=25°C; 1 h; Product distribution / selectivity;
参考文献
US2007/117975 A1, ;
Page/Page column 18 ;
反应条件
1: With sodium tetrahydroborate in methanol T=10 - 20°C; 2 h; 2: With water in methanol Product distribution / selectivity;
参考文献
US2007/117975 A1, ;
Page/Page column 17 ;
