4-氨基吡咯并[2,1-f][1,2,4]三嗪合成路线 （共 8 条）
反应条件
potassium phosphate in ethanol T=78°C; 18 h;
参考文献
WO2007/56170 A2, ;
Page/Page column 73-74 ;
WO 2007/056170 A2
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78°C; 0.25 h; 2: With water in tetrahydrofuran
参考文献
WO2007/64931 A2, ;
Page/Page column 168 ;
反应条件
potassium carbonate in ethanol 2.5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786
反应条件
potassium carbonate Ambient temperature;
参考文献
Patil; Otter; Klein
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 781 - 786
反应条件
1: 1.) aq. hydroxylamine-O-sulfonic acid, 2.) aq. KOH / 1.) 1 h, 2.) 0-5 deg C, 3.5 h 2: 60 percent / ethanol / 2.5 h / Heating 3: 73 percent / aq. K2CO3 / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786
反应条件
1: 60 percent / ethanol / 2.5 h / Heating 2: 73 percent / aq. K2CO3 / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in N,N-dimethyl-formamide T=-20°C; 1.5 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2007/64931 A2, 2007 ;
Location in patent: Page/Page column 164 ;
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane
T=-14 - -10°C; 5 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2007/56170 A2, 2007 ;
Location in patent: Page/Page column 105 ;
WO 2007/056170 A2
