3H-吡咯并[2,1-f][1,2,4]噻嗪-4-酮合成路线 （共 10 条）
反应条件
1: With sodium methylate in methanol Reflux; 2: With hydrogenchloride; water in 1,4-dioxane T=20°C;
参考文献
WO2009/117157 A1, ;
Page/Page column 47-48 ;
WO 2009/117157 A1
参考文献
NEOPHARM CO., LTD.
Patent: US2011/183983 A1, 2011 ;
Location in patent: Page/Page column 32 ;
反应条件
1: With sodium acetate 2: With sodium methylate in methanol
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 16 p. 4054 - 4059
反应条件
sodium methylate in methanol 19 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786
反应条件
1.1: aq. KOH 2.1: NaOAc 2.2: MeONa / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 16 p. 4054 - 4059
反应条件
1: 1.) aq. hydroxylamine-O-sulfonic acid, 2.) aq. KOH / 1.) 1 h, 2.) 0-5 deg C, 3.5 h 2: 60 percent / aq. KOH / 6.5 h / Ambient temperature 3: 81 percent / sodium acetate 4: 73 percent / NaOCH3 / methanol / 19 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786
反应条件
1: 81 percent / sodium acetate 2: 73 percent / NaOCH3 / methanol / 19 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 781 - 786
反应条件
phosphorus oxytribromide T=60°C;
参考文献
AMGEN INC.
Patent: WO2009/117157 A1, 2009 ;
Location in patent: Page/Page column 48 ;
WO 2009/117157 A1
参考文献
Leftheris, Katerina; Hynes, John; Wrobleski, Stephen T.; Barrish, Joel
Patent: US2003/69244 A1, 2003 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=100°C; 20 h; Inert atmosphere; 2: With sodium hydrogencarbonate in water; toluene T=0 - 20°C; 0.5 h;
参考文献
NEOPHARM CO., LTD.
Patent: US2011/183983 A1, 2011 ;
Location in patent: Page/Page column 32 ;
