(2R)-N-[(1S,2S)-1-羟基-1-苯基-2-丙基]-N,2-二甲基-3-苯丙酰胺合成路线 （共 3 条）
反应条件
lithium chloride; lithium diisopropyl amide in tetrahydrofuran T=0°C;
参考文献
Myers, Andrew G.; Yang, Bryant H.; Chen, Hou; McKinstry, Lydia; Kopecky, David J.; Gleason, James L.
Journal of the American Chemical Society, 1997 , vol. 119, # 28 p. 6496 - 6511
反应条件
palladium diacetate; potassium carbonate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in water; toluene T=85°C; Suzuki-Miyaura coupling; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji; Jean-Gerard, Ludivine
Organic Letters, 2010 , vol. 12, # 19 p. 4384 - 4387
反应条件
1: 95 percent / Et3N / CH2Cl2 / 0.5 h / 23 °C 2: 90 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C View Scheme
参考文献
Myers, Andrew G.; Yang, Bryant H.; Chen, Hou; Kopecky, David J.
Synlett, 1997 , # SPEC. ISS. p. 457 - 459
