1: 2-dibenzylamino-propionic acid methyl ester With isopropylmagnesium chloride; O,N-dimethyl-hydroxylamine hydrochloride in tetrahydrofuran -5 deg C, 1 h, 20 deg C, 2h; 2: ethyl magnesium chloride in tetrahydrofuran T=0 - 20°C; 3 h;

1.1: NaHCO3 / tetrahydrofuran; dimethylsulfoxide / 16 h / 85 °C 2.1: HNMe(OMe)*HCl; iPrMgCl / tetrahydrofuran / -5 deg C, 1 h, 20 deg C, 2h 2.2: tetrahydrofuran / 3 h / 0 - 20 °C View Scheme