1: 5-bromopyridin-2-yl amine With sodium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.0833333 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 0.5 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=7 - 8;

sodium hexamethyldisilazane in tetrahydrofuran

1: 5-bromopyridin-2-yl amine With sodium hydride in tetrahydrofuran T=0 - 20°C; 2: di-tert-butyl dicarbonate in tetrahydrofuran 15 h; Reflux;

potassium carbonate; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=80°C; 2 h;

1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78°C; 4 h; 2: With water in tetrahydrofuran Product distribution / selectivity;

N,N,N',N,-tetramethylethylenediamine; hydrogen; di-(1-adamantyl)-n-butylphosphine; palladium diacetate in tetrahydrofuran T=100°C; P=3750.38 Torr; 16 h;