(Ra)-12-hydroxy-1,10-bis(2,4,6-triisopropylphenyl)-4,5,6,7-tetrahydrodiindeno[1,3,2]dioxaphosphocine 12-oxide in methanol; toluene; pentane T=20°C; 12 h; enantioselective reaction;

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 °C / |Inert atmosphere 2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / |Inert atmosphere 2.2: 12 h / -78 - 20 °C / |Inert atmosphere 3.1: (Ra)-12-hydroxy-1,10-bis(2,4,6-triisopropylphenyl)-4,5,6,7-tetrahydrodiindeno[1,3,2]dioxaphosphocine 12-oxide / methanol; toluene; pentane / 12 h / 20 °C View Scheme

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / |Inert atmosphere 1.2: 12 h / -78 - 20 °C / |Inert atmosphere 2.1: (Ra)-12-hydroxy-1,10-bis(2,4,6-triisopropylphenyl)-4,5,6,7-tetrahydrodiindeno[1,3,2]dioxaphosphocine 12-oxide / methanol; toluene; pentane / 12 h / 20 °C View Scheme