反应条件
<b>Multi-step reaction with 13 steps<br /> </b>1: Et<sub>3</sub>N / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 3 °C<br />2: TiCl<sub>4</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / -78 - -15 °C<br />3: aq. HF / acetonitrile / 2 h / Ambient temperature<br />4: 72 percent / O<sub>2</sub>, CuCl, H<sub>2</sub>O / PdCl<sub>2</sub> / dimethylformamide / 15 h / 25 °C<br />5: 41 percent / TESOTf, 2,6-lutidine / CH<sub>2</sub>Cl<sub>2</sub> / 4 h / 25 °C<br />6: 64 percent / 2,6-lutidine / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / -35 °C<br />7: 77 percent / aq. HF / acetonitrile / 1 h / 3 °C<br />8: K<sub>2</sub>CO<sub>3</sub> / methanol / 0.67 h / 3 °C<br />9: 87 percent / 2,6-lutidine / CH<sub>2</sub>Cl<sub>2</sub> / 1.5 h / -45 - 3 °C<br />10: 43 percent / LiHMDS / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 30 min; 0 deg C, 2 h<br />11: 100 percent / LiCl, n-Bu<sub>3</sub>SnH, Pd(PPh<sub>3</sub>)4 / tetrahydrofuran / 3 h / Heating<br />12: 99 percent / aq. HF / acetonitrile / 2 h / 15 °C<br />13: 84 percent / toluene / 3 h / 170 °C<br /> <br />
参考文献
Oikawa, Masato; Ueno, Tohru; Oikawa, Hideaki; Ichihara, Akitami Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5048 - 5068
