2-(4-甲基哌嗪-1-基)苯甲酸合成路线 （共 2 条）
反应条件
1: 1-methyl-piperazine With n-butyllithium in hexane T=-30 - 0°C; 0.5 h; Inert atmosphere; 2: 2-Fluoro-benzoic Acid in tetrahydrofuran; hexane T=-50°C; 14 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=0°C; pH=1; Inert atmosphere;
参考文献
UNIVERSITE DU MAINE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Patent: US2012/316337 A1, 2012 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: 1-methyl-piperazine With n-butyllithium in hexane T=-30 - 0°C; 0.5 h; Inert atmosphere; 2: ortho-methoxybenzoic acid in tetrahydrofuran; hexane T=-50 - 0°C; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=0°C; pH=1; Inert atmosphere;
参考文献
UNIVERSITE DU MAINE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Patent: US2012/316337 A1, 2012 ;
Location in patent: Page/Page column 12-13 ;
