2-BOC-氨基-6-氯吡啶合成路线 （共 13 条）
反应条件
1: With sodium hexamethyldisilazane in tetrahydrofuran T=20°C; Inert atmosphere; 2: With hydrogenchloride in water; ethyl acetate
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/149698 A1, 2012 ;
Location in patent: Page/Page column 26 ;
反应条件
1: 6-chloro-pyridin-3-ylamine in tetrahydrofuran T=0°C; Inert atmosphere; 2: di-tert-butyl dicarbonate With sodium hexamethyldisilazane in tetrahydrofuran T=20°C; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/53929 A1, 2011 ;
Location in patent: Page/Page column 19 ;
US 20110053929 A1
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate T=-15 - -5°C; 5.5 h;
参考文献
US2013/5981 A1, ;
Page/Page column 9 ;
反应条件
diphenylphosphoranyl azide; triethylamine 26 h; Heating;
参考文献
Australian Journal of Chemistry, , vol. 35, # 10 p. 2025 - 2034
反应条件
hydrogen bromide 2 h; Ambient temperature;
参考文献
Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E.
Australian Journal of Chemistry, 1982 , vol. 35, # 10 p. 2025 - 2034
反应条件
1: 1,1-dimethylethyl[6-chloro-2-pyridinyl]carbamate With n-butyllithium; N,N,N',N'-tetraethyl ethylenediamine in tetrahydrofuran; hexane T=-78 - -10°C; 2 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=-10°C; pH=2 - 3;
参考文献
Luk, Kin-Chun
Patent: US2012/184562 A1, 2012 ;
Location in patent: Page/Page column 8; 35 ;
US 20120184562 A1
反应条件
1: 25percent HBr / 2 h / Ambient temperature 2: methanol / 7 h / 140 °C 3: 92 percent / potassium nitrate, concd. H2SO4 / 2 h / 75 °C View Scheme
参考文献
Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E.
Australian Journal of Chemistry, 1982 , vol. 35, # 10 p. 2025 - 2034
反应条件
1: 25percent HBr / 2 h / Ambient temperature 2: methanol / 7 h / 140 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 35, # 10 p. 2025 - 2034
反应条件
1.1: N,N,N',N'-tetraethyl ethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -10 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C
1.3: -10 °C / pH 2 - 3
2.1: methanol / 20 °C / Inert atmosphere
3.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
参考文献
Luk, Kin-Chun
Patent: US2012/184562 A1, 2012 ;
US 20120184562 A1
反应条件
1: 1,1-dimethylethyl[6-chloro-2-pyridinyl]carbamate With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: 1-chloro-4-iodo-butane With copper(l) iodide in tetrahydrofuran
9 h; Heating; Further stages.;
参考文献
Davies, Antony J.; Brands, Karel M. J.; Cowden, Cameron J.; Dolling, Ulf-H.; Lieberman, David R.
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1721 - 1724
