(1r,2s)-1-[(叔丁氧基羰基)氨基]-2-乙烯基环丙烷羧酸甲酯合成路线 (共 7 条)
反应条件
1: various solvent(s); toluene / 17.5 h / 20 °C 2: 95 percent / NaOMe / 2 h / Heating 3: Alcalase 2.4L(R); Na2HPO4*2H2O; KCl / NaOH / acetone; H2O / 70 h / 39 - 41 °C / pH 8.15 View Scheme
参考文献
Beaulieu, Pierre L.; Gillard, James; Bailey, Murray D.; Boucher, Colette; Duceppe, Jean-Simon; Simoneau, Bruno; Wang, Xiao-Jun; Zhang, Li; Grozinger, Karl; Houpis, Ioannis; Farina, Vittorio; Heimroth, Heidi; Krueger, Thomas; Schnaubelt, Juergen
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5869 - 5879
反应条件
2: Et3N, NaN3, ClCOOEt 3: Heating View Scheme
参考文献
Fliche; Braun; Le Goffic
Synthetic Communications, 1994 , vol. 24, # 20 p. 2873 - 2876
反应条件
1: Et3N, NaN3, ClCOOEt 2: Heating View Scheme
参考文献
Fliche; Braun; Le Goffic
Synthetic Communications, 1994 , vol. 24, # 20 p. 2873 - 2876
参考文献
Beaulieu, Pierre L.; Gillard, James; Bailey, Murray D.; Boucher, Colette; Duceppe, Jean-Simon; Simoneau, Bruno; Wang, Xiao-Jun; Zhang, Li; Grozinger, Karl; Houpis, Ioannis; Farina, Vittorio; Heimroth, Heidi; Krueger, Thomas; Schnaubelt, Juergen
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5869 - 5879
参考文献
Beaulieu, Pierre L.; Gillard, James; Bailey, Murray D.; Boucher, Colette; Duceppe, Jean-Simon; Simoneau, Bruno; Wang, Xiao-Jun; Zhang, Li; Grozinger, Karl; Houpis, Ioannis; Farina, Vittorio; Heimroth, Heidi; Krueger, Thomas; Schnaubelt, Juergen
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5869 - 5879
参考文献
Fliche; Braun; Le Goffic
Synthetic Communications, 1994 , vol. 24, # 20 p. 2873 - 2876
反应条件
1: With lithium hydroxide; water in tetrahydrofuran; methanol T=20°C; 19 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=1;
参考文献
Gilead Sciences, Inc.
Patent: US2009/47252 A1, 2009 ;
Location in patent: Page/Page column 33-34 ;