triethylamine; 2-dicyclohexylphosphino-1,1'-biphenyl; palladium diacetate in 1,4-dioxane T=80°C; 1 h;

1: N-Boc-2-bromoaniline With methyllithium in diethyl ether T=20°C; Inert atmosphere; 2: With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 1 h; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol Further stages;

triethylamine; 2-dicyclohexylphosphino-1,1'-biphenyl; palladium diacetate T=80°C; 1 h;

1: N-Boc-2-bromoaniline With n-butyllithium in tetrahydrofuran; pentane T=-78°C; 0.25 h; Inert atmosphere; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; pentane T=-78 - 20°C; Inert atmosphere;

hydrogenchloride; sodium; sodium carbonate; Merrifield resin; tetrakis(triphenylphosphine) palladium(0) 2.) DME, reflux, 48 h; 3.) dioxan, 80 deg C, 48 h; Yield given. Multistep reaction;

tetrakis(triphenylphosphine) palladium(0); sulfuric acid; sodium carbonate 1.) DME, from 85 deg C to 90 deg C, 6.25 h, 2.) DME, RT, 10 min; Yield given. Multistep reaction;