3-亚甲基环丁烷羧酸甲酯合成路线 （共 17 条）
反应条件
potassium carbonate in acetone 2 h; Reflux;
参考文献
ACHAOGEN, INC.; KASAR, Ramesh; LINSELL, Martin Sheringham; AGGEN, James Bradley; LU, Qing (Jane); WANG, Dan; CHURCH, Tim; MOSER, Heinz E.; PATTEN, Phillip A.
Patent: WO2012/154204 A1, 2012 ;
Location in patent: Page/Page column 67; 68 ;
反应条件
diazomethyl-trimethyl-silane in hexanes; dichloromethane T=0°C; 0.5 h;
参考文献
IRM LLC; TULLY, David C.; RUCKER, Paul Vincent; ALPER, Phillip B.; MUTNICK, Daniel; CHIANELLI, Donatella
Patent: WO2012/87519 A1, 2012 ;
Location in patent: Page/Page column 104 ;
WO 2012/087519 A1
反应条件
potassium tert-butylate in dimethyl sulfoxide
参考文献
Surmina, L. S.; Zefirov, N. S.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 4 p. 777 - 778
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 4 p. 870
反应条件
1: aq. KOH / methanol 2: diethyl ether View Scheme
参考文献
ACHAOGEN, INC.; KASAR, Ramesh; LINSELL, Martin Sheringham; AGGEN, James Bradley; LU, Qing (Jane); WANG, Dan; CHURCH, Tim; MOSER, Heinz E.; PATTEN, Phillip A.
Patent: WO2012/154204 A1, 2012 ;
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
Surmina, L. S.; Zefirov, N. S.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 4 p. 777 - 778
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 4 p. 870
反应条件
1: aq. KOH / ethanol 2: 160 °C / 1 Torr 3: aq. HBr 4: (i) Ag2O, CCl4, (ii) /BRN= 102415/, Et2O View Scheme
参考文献
Musso,H. et al.
Chemische Berichte, 1967 , vol. 100, p. 3614 - 3624
参考文献
Cripps et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2723,2725
反应条件
(i) aq. NaOH, (ii) /BRN= 102415/; Multistep reaction;
参考文献
Gajewski,J.J.
Journal of the American Chemical Society, 1970 , vol. 92, p. 3688 - 3696
参考文献
Hanack,M.; Riedlinger,K.
Chemische Berichte, 1967 , vol. 100, p. 2107 - 2116
Full Text Show Details
Ooba,S. et al.
Bulletin of the Chemical Society of Japan, 1967 , vol. 40, p. 144 - 146
反应条件
1: aq. HBr 2: (i) Ag2O, CCl4, (ii) /BRN= 102415/, Et2O View Scheme
参考文献
Musso,H. et al.
Chemische Berichte, 1967 , vol. 100, p. 3614 - 3624
