N-[N-[(1,1-二甲基乙氧基)羰基]-2-甲基丙氨酰]-D-色氨酸合成路线 （共 9 条）
反应条件
4-methyl-morpholine in 1,4-dioxane; water; ethyl acetate
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 7 p. 759 - 764
反应条件
1: HOBt, EDC / Ambient temperature 2: H2 / Pd/C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 11 p. 1431 - 1436
反应条件
1: EDC, HOBt, DIEA / CH2Cl2 2: H2 / Pd/C / ethanol / 760 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 7 p. 759 - 764
反应条件
1: EDC, DMAP / CH2Cl2 / 0 °C 2: HCl / ethyl acetate / 0 °C 3: HOBt, EDC / Ambient temperature 4: H2 / Pd/C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 11 p. 1431 - 1436
反应条件
1: HCl / ethyl acetate / 0 °C 2: HOBt, EDC / Ambient temperature 3: H2 / Pd/C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 11 p. 1431 - 1436
反应条件
1: triethylamine; 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 38 °C / |Inert atmosphere; |Large scale 2: sodium hydroxide / water; tert-butyl methyl ether / 20 °C / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 2 p. 339 - 345
参考文献
Organic Process Research and Development, , vol. 10, # 2 p. 339 - 345
反应条件
1.1: 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C 1.2: 20 °C 2.1: hydrogenchloride / ethyl acetate View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 2 p. 339 - 345
