3,4-二甲氧基苯乙酸甲酯合成路线 （共 36 条）
反应条件
1.1: tin(ll) chloride / 20 °C
2.1: hydrazine hydrate / ethanol / 3 h / 150 °C
2.2: 0.5 h / Reflux
3.1: N,N-dimethyl-aniline; trichlorophosphate / chloroform / 120 °C
4.1: tetrahydrofuran / -78 °C
View Scheme
参考文献
Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572
反应条件
1: AlCl3
2: ethanol; ammonia / 130 - 140 °C
View Scheme
参考文献
Bentley et al.
Journal of the Chemical Society, 1952 , p. 1763,1766
反应条件
1.1: tin(ll) chloride / 20 °C
2.1: hydrazine hydrate / ethanol / 3 h / 150 °C
2.2: 0.5 h / Reflux
3.1: N,N-dimethyl-aniline; trichlorophosphate / chloroform / 120 °C
View Scheme
参考文献
Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572
反应条件
1: (i) LiAlH4, Et2O, (ii) aq. H2SO4
2: SOCl2, PhNMe2 / CHCl3
3: NaI / ethanol
4: H2O; ethanol
View Scheme
参考文献
Sargent,L.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1754 - 1758
反应条件
1: (i) NaNH2, Fe(NO3)3, liq. NH3, (ii) /BRN= 1098244/
2: (i) NaNH2, Fe(NO3)3, liq. NH3, (ii) /BRN= 605308/
3: aq. KOH / dimethylsulfoxide / 48 h / 90 °C
4: (i) PCl5, Et2O, (ii) liq. NH3, bis-(2,3-dimethyl-propyl)-borane, THF, (iii) aq. H2O2
5: 2,2,2-trichloro-<1,3,2>benzodioxaphospholane / 100 °C
6: 4 h / 130 °C
View Scheme
参考文献
Ramuz
Helvetica chimica acta, 1975 , vol. 58, # 7 p. 2050 - 2060
反应条件
1: (i) LiAlH4, Et2O, (ii) aq. H2SO4
2: SOCl2, PhNMe2 / CHCl3
3: NaI / ethanol
4: H2O; ethanol
5: aq. KOH / methanol
6: Br2 / acetic acid
View Scheme
参考文献
Sargent,L.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1754 - 1758
