2-氯-1-甲基-5-硝基-1H-苯并咪唑合成路线 （共 11 条）
反应条件
1: 2-chloro-5-nitro-1H-benzimidazole With sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 2 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 3 h;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2005/35526 A1, 2005 ;
Location in patent: Page/Page column 52-53 ;
WO 2005/035526 A1
反应条件
phosphorus pentachloride; trichlorophosphate T=190°C;
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6114532 A1, 2000 ;
US 6114532 A
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 1 h; 2: With N-chloro-succinimide in tetrahydrofuran; n-heptane; ethylbenzene T=20°C; 0.166667 h; Further stages.;
参考文献
Piersanti, Giovanni; Giorgi, Luca; Bartoccini, Francesca; Tarzia, Giorgio; Minetti, Patrizia; Gallo, Grazia; Giorgi, Fabrizio; Castorina, Massimo; Ghirardi, Orlando; Carminati, Paolo
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2567 - 2571
反应条件
thionyl chloride Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/74515 A1, 2003 ;
Location in patent: Page/Page column 103 ;
WO 03/074515 A1
反应条件
sulfuric acid; nitric acid T=10°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Galy, Jean-Pierre; Hanoun, Jean-Pierre; Pique, Valerie; Jagerovic, Nadine; Elguero, Jose
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1781 - 1787
反应条件
1: 84 percent / 5N aq. NaOH / 1 h / Ambient temperature 2: conc. HNO3, conc. H2SO4 / 1 h / 10 °C View Scheme
参考文献
Galy, Jean-Pierre; Hanoun, Jean-Pierre; Pique, Valerie; Jagerovic, Nadine; Elguero, Jose
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1781 - 1787
反应条件
2: POCl3; PCl5 / 190 °C View Scheme
参考文献
van Romburgh; Huyser
Recueil des Travaux Chimiques des Pays-Bas, 1930 , vol. 49, p. 165,175
反应条件
2: POCl3; PCl5 / 190 °C View Scheme
参考文献
van Romburgh; Huyser
Recueil des Travaux Chimiques des Pays-Bas, 1930 , vol. 49, p. 165,175
参考文献
van Romburgh; Huyser
Verslag van de Gewone Vergadering van de Afdeling Natuurkunde, Koninklijke Nederlandse Akademie van Wetenschappen, vol. 35, p. 669
Chem. Zentralbl., 1926 , vol. 97, # II p. 2064
反应条件
1: With hydrogenchloride; tin(ll) chloride in water T=100°C; 3.25 h; 2: With sodium hydroxide in water pH=9;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2005/35526 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
WO 2005/035526 A1
