3-(4-硝基-苯基)-异噁唑-5-羧酸乙酯合成路线 （共 11 条）
反应条件
1: pyridine / 12 h / 0 - 20 °C 2: DIPEA / Pd(PPh3)2Cl2; CuI / dimethylformamide / 48 h / 45 °C 3: aq. NaOH / diethyl ether; methanol / 18 h 4: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
1: DIPEA / Pd(PPh3)2Cl2; CuI / dimethylformamide / 48 h / 45 °C 2: aq. NaOH / diethyl ether; methanol / 18 h 3: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
potassium hydrogencarbonate; copper(II) sulfate; sodium L-ascorbate in water; tert-butyl alcohol T=50°C; 24 h;
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
1: aq. NaOH / diethyl ether; methanol / 18 h 2: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
trifluoroacetic acid; sodium nitrite T=20°C; 0.666667 h; regioselective reaction;
参考文献
Kadzhaeva; Trofimova; Fedotov; Potekhin; Gazzaeva; Mochalov; Zefirov
Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 5 p. 595 - 605
反应条件
trifluoroacetic acid; sodium nitrite T=20°C; 12 h;
参考文献
Kadzhaeva; Trofimova; Fedotov; Potekhin; Gazzaeva; Mochalov; Zefirov
Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 5 p. 595 - 605
参考文献
Cusmano
Gazzetta Chimica Italiana, 1939 , vol. 69, p. 214,218
参考文献
Cusmano
Gazzetta Chimica Italiana, 1939 , vol. 69, p. 214,218
参考文献
Cusmano
Gazzetta Chimica Italiana, 1939 , vol. 69, p. 214,218
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
