6-甲基-5-硝基苯并噻吩-2-甲酸乙酯合成路线 （共 3 条）
反应条件
1: 63 percent / conc. H2SO4, conc. HNO3 / 0.33 h / 15 °C 2: 1.) NaOEt / 1.) EtOH, 5 deg C, 20 min, 2.) EtOH, reflux, 3 h View Scheme
参考文献
Forbes, Ian T.; Dabbs, Steven; Duckworth, D. Malcolm; Ham, Peter; Jones, Graham E.; King, Frank D.; Saunders, Damian V.; Blaney, Frank E.; Naylor, Christopher B.; Baxter, Gordon S.; Blackburn, Thomas P.; Kennett, Guy A.; Wood, Martyn D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4966 - 4977
反应条件
sodium ethanolate 1.) EtOH, 5 deg C, 20 min, 2.) EtOH, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Forbes, Ian T.; Dabbs, Steven; Duckworth, D. Malcolm; Ham, Peter; Jones, Graham E.; King, Frank D.; Saunders, Damian V.; Blaney, Frank E.; Naylor, Christopher B.; Baxter, Gordon S.; Blackburn, Thomas P.; Kennett, Guy A.; Wood, Martyn D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4966 - 4977
反应条件
1: 100 percent / aq. NaOH / ethanol / 3 h / Heating 2: 89 percent / Cu, quinoline / 3 h / 190 °C 3: 1.) pyrrolidine, 2.) aq. HCl / 1.) DMF, 150 deg C, 3 h, 2.) toluene, reflux, 30 min 4: 98 percent / NaBH4 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Forbes, Ian T.; Dabbs, Steven; Duckworth, D. Malcolm; Ham, Peter; Jones, Graham E.; King, Frank D.; Saunders, Damian V.; Blaney, Frank E.; Naylor, Christopher B.; Baxter, Gordon S.; Blackburn, Thomas P.; Kennett, Guy A.; Wood, Martyn D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4966 - 4977
