2-氨基-5-甲基-4-嘧啶醇合成路线 （共 8 条）
反应条件
1: formic acid methyl ester; propionic acid ethyl ester With sodium methylate in N,N-dimethyl-formamide T=20°C; 2: 1-methylguanidine hydrochloride in methanol; N,N-dimethyl-formamide 12 h; Reflux;
参考文献
Ruah, Sara Hadida; Miller, Mark; Zhou, Jinglan; Bear, Brian
Patent: US2009/221597 A1, 2009 ;
Location in patent: Page/Page column 40; 41 ;
US 20090221597 A1
参考文献
Watanabe, K. A.; Su, T.-L.; Pankiewicz, K. W.; Harada, K.
Heterocycles, 1984 , vol. 21, # 1 p. 289 - 307
反应条件
sulfuric acid; sulfur trioxide
参考文献
Scherp
Journal of the American Chemical Society, 1946 , vol. 68, p. 912
反应条件
in methanol; N,N-dimethyl-formamide 2 h; Heating; Yields of byproduct given;
参考文献
Stoss; Kaes; Eibel; Thewalt
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 231 - 236
参考文献
Johnson; Clapp
American Chemical Journal, 1904 , vol. 32, p. 144
参考文献
Hull et al.
Journal of the Chemical Society, 1947 , p. 41,45
反应条件
hydrogenchloride; sodium nitrite in water T=70°C; 8 h;
参考文献
Stoss; Kaes; Eibel; Thewalt
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 231 - 236
反应条件
1: With trichlorophosphate 0.75 h; Reflux; 2: With ammonia in water T=10°C;
参考文献
Ruah, Sara Hadida; Miller, Mark; Zhou, Jinglan; Bear, Brian
Patent: US2009/221597 A1, 2009 ;
Location in patent: Page/Page column 41 ;
US 20090221597 A1
