1: LiBH4 / tetrahydrofuran / 12 h / Ambient temperature 2: 94 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 3: 98 percent / Bu4NF / tetrahydrofuran / 2 h / Ambient temperature 4: 93 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / Ambient temperature View Scheme

1: LiBH4 / tetrahydrofuran / 12 h / Ambient temperature 2: 94 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 3: 98 percent / Bu4NF / tetrahydrofuran / 2 h / Ambient temperature View Scheme

Condensation;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: K₂CO₃ / dimethylformamide / 1.) 0 deg C, 40 min; 2.) RT, 2 h<br />2: 77 percent / imidazole / dimethylformamide / 0.5 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: pyridine; Et₃N / CH₂Cl₂ / 2 h / 20 &deg;C<br />2: imidazole / dimethylformamide / 11 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 100 percent / Et₃N<br />2: 100 percent<br /> <br /> &nbsp;