4-氨基-3-氰基苯甲酸甲酯合成路线 （共 4 条）
反应条件
1: 31 percent / dimethylformamide / 21 h / 140 °C 2: 2.) conc. HCl / 1.) phosphate buffer pH 7.0, nitrilase SP 361, 30 deg C, 49 h, 2.) reflux, 65 h View Scheme
参考文献
Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicolas J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1679 - 1688
反应条件
hydrogenchloride 1.) phosphate buffer pH 7.0, nitrilase SP 361, 30 deg C, 49 h, 2.) reflux, 65 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicolas J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1679 - 1688
反应条件
Rhodococcus SRL4281 96 h;
参考文献
Allen, John; Brasseur, Denis M.; De Bruin, Beatrice; Denoux, Mireille; Perard, Serge; Philippe, Nicolas; Roy, Sebastien N.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 342 - 346
反应条件
1: With lithium hydroxide; water in tetrahydrofuran
T=20°C; 20 h;
2: With hydrogenchloride in tetrahydrofuran; water
pH=3;
参考文献
NEUROSEARCH A/S
Patent: WO2004/22529 A2, 2004 ;
Location in patent: Page 33 ;
WO 2004/022529 A2
