2-氨基-5-氰基苯甲酸甲酯合成路线 （共 8 条）
反应条件
zink cyanide; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide) T=90 - 100°C; 8 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18428 A1, 2004 ;
Location in patent: Page 369 ;
反应条件
1: in 1-methyl-pyrrolidin-2-one 5 h; Heating / reflux; 2: With hydrogenchloride; anhydrous iron chloride in 1-methyl-pyrrolidin-2-one; water T=60°C; 1 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/9967 A2, 2005 ;
Location in patent: Page/Page column 78-79 ;
WO 2005/009967 A2
反应条件
in 1-methyl-pyrrolidin-2-one T=180°C; 4 h;
参考文献
Gillespie, Paul
Patent: US2013/79346 A1, 2013 ;
Location in patent: Paragraph 0277-0278 ;
反应条件
1: 31 percent / dimethylformamide / 21 h / 140 °C 2: 2.) conc. HCl / 1.) phosphate buffer pH 7.0, nitrilase SP 361, 30 deg C, 49 h, 2.) reflux, 65 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 13 p. 1679 - 1688
反应条件
thionyl chloride Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8332 - 8338
反应条件
hydrogenchloride 1.) phosphate buffer pH 7.0, nitrilase SP 361, 30 deg C, 49 h, 2.) reflux, 65 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 13 p. 1679 - 1688
反应条件
sodium hydroxide in methanol; water
T=20°C; 27.5 h;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18428 A1, 2004 ;
Location in patent: Page 347 ;
反应条件
Rhodococcus SRL4281; Agrobacterium DSM6336; NIT-102; NIT-105
24 h;
参考文献
Allen, John; Brasseur, Denis M.; De Bruin, Beatrice; Denoux, Mireille; Perard, Serge; Philippe, Nicolas; Roy, Sebastien N.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 342 - 346
