1-(2,3-环氧基丙基)-4-叔丁氧基羰基哌嗪合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol
参考文献
Gyogyszerkutato Intezet KFT
Patent: US5380724 A1, 1995 ;
反应条件
potassium carbonate in acetonitrile T=20°C; 48 h;
参考文献
Bombrun, Agnes; Gerber, Patrick; Casi, Giulio; Terradillos, Olivier; Antonsson, Bruno; Halazy, Serge
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4365 - 4368
参考文献
Applied Research Systems ARS Holding N.V.
Patent: EP1094063 A1, 2001 ;
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C 1.2: 72 percent / tetrahydrofuran / 16 h / 20 °C 2.1: TFA / CH2Cl2 / 0.67 h / 20 °C View Scheme
参考文献
Bombrun, Agnes; Gerber, Patrick; Casi, Giulio; Terradillos, Olivier; Antonsson, Bruno; Halazy, Serge
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4365 - 4368
