[(1R,2S)-3-氯-2-羟基-1-[(苯基硫)甲基]丙基]氨基甲酸苄酯合成路线 （共 6 条）
反应条件
hydrogenchloride in isopropyl alcohol
参考文献
Hoffmann-La Roche Inc.
Patent: US6130348 A1, 2000 ;
反应条件
1: sodium tetrahydroborate; calcium chloride / methanol / 4 h / 20 - 30 °C 2: pyridinium p-toluenesulfonate / 24 h / 20 °C 3: triethylamine / toluene / 2 h / 5 - 20 °C 4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 10 - 20 °C 5: hydrogenchloride / methanol; water / 1.5 h / 80 °C 6: triethylamine; thionyl chloride / dichloromethane / 0.17 h / 20 °C / |Cooling with ice 7: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 6, # 1 p. 49 - 53
反应条件
1: triethylamine / toluene / 2 h / 5 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 10 - 20 °C 3: hydrogenchloride / methanol; water / 1.5 h / 80 °C 4: triethylamine; thionyl chloride / dichloromethane / 0.17 h / 20 °C / |Cooling with ice 5: lithium chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 6, # 1 p. 49 - 53
反应条件
1: 4-methyl-morpholine / dichloromethane 2: diethyl ether 3: hydrogenchloride 4: sodium tetrahydroborate / ethanol View Scheme
参考文献
Organic Process Research and Development, , vol. 6, # 6 p. 884 - 892
反应条件
sodium tetrahydroborate in ethanol
参考文献
Organic Process Research and Development, , vol. 6, # 6 p. 884 - 892
反应条件
sodium hydroxide in water; isopropyl alcohol T=22 - 45°C; 1 - 2 h;
参考文献
AGOURON PHARMACEUTICALS, INC.; JAPAN TOBACCO INC.
Patent: EP1361216 A1, 2003 ;
Location in patent: Page/Page column 28 ;
