1.1: 60.3 percent / propan-2-ol / 5 h / Heating 2.1: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C 3.1: HOBt; BOP; DIPEA / dimethylformamide / 0.17 h / 0 °C 3.2: Et3N / dimethylformamide / 0 - 20 °C 4.1: HCl / dioxane / 0 - 20 °C 5.1: DIPEA / dimethylformamide / 0 - 20 °C View Scheme

1.1: 60.3 percent / propan-2-ol / 5 h / Heating 2.1: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C 3.1: HOBt; BOP; DIPEA / dimethylformamide / 0.17 h / 0 °C 3.2: Et3N / dimethylformamide / 0 - 20 °C 4.1: HCl / dioxane / 0 - 20 °C 5.1: DIPEA / dimethylformamide / 0 - 20 °C View Scheme

1.1: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C 2.1: HOBt; BOP; DIPEA / dimethylformamide / 0.17 h / 0 °C 2.2: Et3N / dimethylformamide / 0 - 20 °C 3.1: HCl / dioxane / 0 - 20 °C 4.1: DIPEA / dimethylformamide / 0 - 20 °C View Scheme

N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=0 - 20°C;

1.1: HOBt; BOP; DIPEA / dimethylformamide / 0.17 h / 0 °C 1.2: Et3N / dimethylformamide / 0 - 20 °C 2.1: HCl / dioxane / 0 - 20 °C 3.1: DIPEA / dimethylformamide / 0 - 20 °C View Scheme

1: HCl / dioxane / 0 - 20 °C 2: DIPEA / dimethylformamide / 0 - 20 °C View Scheme