(2S)-1-[(1,1-二甲基乙氧基)羰基]-2-哌啶乙酸合成路线 （共 4 条）
反应条件
sodium hydroxide in water; tert-butyl alcohol 16 h; Ambient temperature;
参考文献
Morley, Christopher; Knight, David W.; Share, Andrew C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 20 p. 2903 - 2908
反应条件
Burkholderia cepacia lipase; hydrogenchloride in tetrahydrofuran; phosphate buffer T=25°C; pH=7; 96 h;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 21 p. 3407 - 3412
反应条件
1: Jones reagent 2: 86 percent / NaOH / H2O; 2-methyl-propan-2-ol / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 20 p. 2903 - 2908
反应条件
1: (2S)-1-tert-butoxycarbonyl-2-carboxymethylpiperidine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 0.333333 h; 2: methanol in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David; BELVEDERE, Sandro
Patent: WO2010/60471 A1, 2010 ;
Location in patent: Page/Page column 15-16 ;
WO 2010/060471 A1
