反应条件
1.1: potassium tert-butylate / tert-butyl alcohol / Reflux 2.1: sodium tetrahydroborate / tetrahydrofuran; acetic acid / 20 °C 3.1: hydrogenchloride; 2,2,2-trifluoroethanol / 1,3-dimercaptopropane 4.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C 5.2: 20 °C 6.1: trifluoroacetic acid / dichloromethane; water / 20 °C 7.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C 8.1: chloro-trimethyl-silane / tetrahydrofuran / 2 h / -40 °C 9.1: palladium 10 on activated carbon; hydrogen / ethanol 10.1: 4-(N,N-dimethlyamino)pyridine / pyridine / 0 - 20 °C 11.1: ammonium cerium (IV) nitrate / water; acetonitrile / 20 °C 12.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 20 °C / Reflux 13.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C 14.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide / tetrahydrofuran; hexane / 4 h / -78 °C 15.1: trifluoroacetic acid / dichloromethane / 4 - 20 °C 16.1: water; sodium hydroxide / 64 h / 4 °C 17.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 2 h View Scheme
参考文献
Gu, Wenxin; Silverman, Richard B.
Journal of Organic Chemistry, 2011 , vol. 76, # 20 p. 8287 - 8293
