甲基4-(4-氟苯基)-6-异丙基-2-(甲硫基)嘧啶-5-羧酸酯合成路线 (共 6 条)
反应条件
chloranil in toluene T=65 - 70°C; 5 h;
参考文献
KHAMAR, Bakulesh, Mafatlal; MODI, Indravadan, Ambalal; VENKATRAMAN, Jayaraman; RAVI, Ponnaiah; DESAI, Sanjay, Jagadish; RAJPUT, Amarsingh, L.
Patent: WO2007/74391 A2, 2007 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: 4-methyl-3-oxopentanoic acid methyl ester; 4-fluorobenzaldehyde With acetic acid; 3-aminopropionic acid in cyclohexane T=20°C; 20.25 - 24.25 h; Heating / reflux; 2: With sodium carbonate in cyclohexane; water 3: S-methylisothiourea sulfate With 2,3-dicyano-5,6-dichloro-p-benzoquinone Product distribution / selectivity; more than 3 stages;
参考文献
GLENMARK PHARMACEUTICALS LIMITED
Patent: WO2008/59519 A2, 2008 ;
Location in patent: Page/Page column 8; 14-15; 18-20 ;
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=100°C; 24 h;
参考文献
WO2005/30758 A1, ;
Page/Page column 58-59 ;
WO 2005/030758 A1
反应条件
1: S-methylisothiourea sulfate With sodium carbonate in acetonitrile T=20°C; 0.5 h; 2: methyl 2-(4-fluorobenzoyl)-3-methoxy-3-isopropylpropenoate in acetonitrile T=80°C; Product distribution / selectivity;
参考文献
EP1849765 A1, ;
Page/Page column 14 ;
反应条件
1: With diisobutylaluminium hydride in toluene T=20°C; 2 - 3 h; Cooling with ice/salt; 2: With water in toluene
参考文献
Yao, Hui; Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP1845092 A1, 2007 ;
Location in patent: Page/Page column 14; 16 ;
反应条件
ammonium peroxomolybdate; dihydrogen peroxide; Aliquatreg; 336 in dichloromethane; water T=20 - 35°C; 19 - 21.5 h; Product distribution / selectivity;
参考文献
WO2008/59519 A2, ;
Page/Page column 8; 15-16; 20 ;