4-(4-氟苯基)-2-(甲基氨基)-6-异丙基嘧啶-5-羧酸甲酯合成路线 （共 6 条）
反应条件
in dichloromethane T=-10 - 20°C;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2003/97614 A2, 2003 ;
Location in patent: Page/Page column 4; 11 ;
反应条件
in ethanol T=0 - 20°C; 1 h;
参考文献
CIBA SPECIALTY CHEMICALS HOLDING INC.
Patent: WO2004/103977 A2, 2004 ;
Location in patent: Page 22 ;
反应条件
1: 1-methylguanidine-hydrochloride With sodium carbonate in acetonitrile T=20°C; 0.5 h; 2: methyl 2-(4-fluorobenzoyl)-3-methoxy-3-isopropylpropenoate in acetonitrile T=80°C;
参考文献
EP1849765 A1, ;
Page/Page column 14 ;
反应条件
1: sodium bicarbonate / dimethylformamide / 75 °C 2: 88 percent / CuCl2; K2CO3; aq. tert-butylhydroperoxide / CH2Cl2 / 38 - 40 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 21 p. 4673 - 4676
反应条件
1: sodium bicarbonate / dimethylformamide / 75 °C 2: 88 percent / CuCl2; K2CO3; aq. tert-butylhydroperoxide / CH2Cl2 / 38 - 40 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 21 p. 4673 - 4676
反应条件
1: 6-(4'-fluorophenyl)-4-isopropyl-5-methoxycarbonyl-2-(methylamino)pyrimidine With sodium tert-pentoxide in ethylene glycol dimethyl ether T=20°C; 0.5 h; 2: methanesulfonyl chloride in ethylene glycol dimethyl ether T=-10°C; 0.5 h;
参考文献
WO2004/103977 A2, ;
Page 22-23 ;
