2-氨基-4-(4-氟苯基)-6-异丙基-嘧啶-5-羧酸甲酯合成路线 （共 3 条）
参考文献
Lonza AG
Patent: US6579984 B1, 2003 ;
反应条件
1: methyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-pyrimidine-5-carboxylate With sodium tert-pentoxide in ethylene glycol dimethyl ether T=25°C; 0.5 h; 2: methanesulfonyl chloride in ethylene glycol dimethyl ether T=-10 - -5°C; 0.333333 h; 3: With sodium tert-pentoxide; dimethyl sulfate more than 3 stages;
参考文献
US2004/49036 A1, ;
Page 3 ;
反应条件
sodium chloride; dimethyl sulfate in ethylene glycol dimethyl ether; water
