2,4-二溴-5-(三甲基甲硅烷基)呋喃合成路线 (共 4 条)
反应条件
1: 2,3-dibromofuran With lithium diisopropyl amide in tetrahydrofuran; diethyl ether; n-heptane; ethylbenzene T=-78°C; 0.166667 h; 2: chloro-trimethyl-silane in tetrahydrofuran; diethyl ether; n-heptane; ethylbenzene T=-78 - 20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/5435 A1, 2005 ;
Location in patent: Page/Page column 25-26 ;
WO 2005/005435 A1
反应条件
n-butyllithium; diisopropylamine; lithium diisopropyl amide in tetrahydrofuran; hexane T=-50°C; 0.25 h;
参考文献
Froehlich, J.
Bulletin des Societes Chimiques Belges, 1996 , vol. 105, # 10-11 p. 615 - 634
反应条件
n-butyllithium; diisopropylamine; lithium diisopropyl amide in tetrahydrofuran; hexane T=-50°C; 0.25 h;
参考文献
Froehlich, J.
Bulletin des Societes Chimiques Belges, 1996 , vol. 105, # 10-11 p. 615 - 634
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol
T=100°C; 6 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/5435 A1, 2005 ;
Location in patent: Page/Page column 41 ;
WO 2005/005435 A1