N-(5-氯-4-甲氧基-2-硝基苯基)乙酰胺合成路线 （共 10 条）
反应条件
sulfuric acid; nitric acid T=0°C;
参考文献
Ahmad, Arshad; Dunbar, Linda J.; Green, Iain G.; Harvey, Ian W.; Shepherd, Thomas; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 19 p. 2751 - 2758
反应条件
1: acetic acid / 0.25 h / Heating 2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 89 percent / iron, acetic acid / H2O / 3 h / Heating 2: 80 percent / acetic acid / 0.25 h / 100 °C 3: 73 percent / conc. nitric acid, conc. H2SO4 / 0 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 19 p. 2751 - 2758
反应条件
hydrogenchloride in ethanol; water 0.5 h; Heating / reflux;
参考文献
Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 43, 44 ;
US 20030236287 A1
参考文献
Aventis Pharmaceuticals Product, Inc.
Patent: US6159978 A1, 2000 ;
US 6159978 A
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 100 °C
2: hydrogenchloride; water / ethanol / Reflux
3: phosphoric acid / 100 °C
4: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
5: sodium tetrahydroborate; acetic acid / 20 °C
6: hydrazine hydrate / ethanol / Reflux
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 100 °C
2: hydrogenchloride; water / ethanol / Reflux
3: phosphoric acid / 100 °C
4: 10 palladium on activated charcoal; hydrazine hydrate / ethanol / Reflux
5: sodium tetrahydroborate; acetic acid / 20 °C
6: hydrazine hydrate / ethanol / Reflux
7: ethanol
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 100 °C
2: hydrogenchloride; water / ethanol / Reflux
3: phosphoric acid / 100 °C
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: potassium hydroxide / N,N-dimethyl-formamide / 100 °C
2: hydrogenchloride; water / ethanol / Reflux
3: phosphoric acid / 100 °C
View Scheme
参考文献
Chaurasiya, Narayan D.; Ganesan, Shobana; Nanayakkara, N.P. Dhammika; Dias, Luiza R.S.; Walker, Larry A.; Tekwani, Babu L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1701 - 1704
反应条件
1: 57 percent / HCl / 1 h / Heating
2: 35 percent / sodium dithionite / H2O / Heating
View Scheme
参考文献
Ahmad, Arshad; Dunbar, Linda J.; Green, Iain G.; Harvey, Ian W.; Shepherd, Thomas; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 19 p. 2751 - 2758
