N-(苄氧羰基)-L-丙氨酰-L-丙氨酸合成路线 （共 33 条）
反应条件
1: chloroform; aqueous KHCO3 / -50 °C
2: acetone; aqueous NaOH
View Scheme
参考文献
Stein; Moore; Bergmann
Journal of Biological Chemistry, 1944 , vol. 154, p. 198
参考文献
Noguchi,J. et al.
Israel Journal of Chemistry, 1974 , vol. 12, p. 87 - 101
反应条件
2-Hydroxypyridine; dicyclohexyl-carbodiimide
参考文献
Kapoor; Davis; Graetzer
Journal of pharmaceutical sciences, 1968 , vol. 57, # 9 p. 1514 - 1519
反应条件
(i) (heating), xylene, (ii) aq. KOH, MeOH; Multistep reaction;
参考文献
Kaneko,T. et al.
Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 974 - 979
反应条件
(i) <Me4N>OH, (ii) /BRN= 2916827/, N,N,N',N'-tetramethyl-guanidine, DMSO; Multistep reaction;
参考文献
Kemp,D.S. et al.
Tetrahedron, 1974 , vol. 30, p. 3969 - 3980
反应条件
in N,N-dimethyl-formamide; acetonitrile
T=20°C; Acylation; hydrolysis; Product distribution;
参考文献
Voyushina, Tatiana L.; Potetinova, Joanna V.; Milgotina, Ekaterina I.; Stepanov, Valentin M.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 2953 - 2959
反应条件
Streptomyces bikiniensis 27 (VKPM Ac-1783) carboxypeptidase
T=37°C; pH=7.6; aq. Tris-HCl bufferEnzymatic reaction; Kinetics;
参考文献
Serkina; Zalunin; Levitin; Voejkova; Tyaglov; Novikova; Emeljanova; Konstantinova; Chestukhina
Biochemistry (Moscow), 2010 , vol. 75, # 8 p. 1032 - 1038
反应条件
Streptomyces bikiniensis 27 (VKPM Ac-1783) carboxypeptidase
T=37°C; pH=7.6; aq. Tris-HCl bufferEnzymatic reaction; Kinetics;
参考文献
Serkina; Zalunin; Levitin; Voejkova; Tyaglov; Novikova; Emeljanova; Konstantinova; Chestukhina
Biochemistry (Moscow), 2010 , vol. 75, # 8 p. 1032 - 1038
参考文献
Brown, D. W.; Campbell, M. M.; Walker, C. V.
Tetrahedron, 1983 , vol. 39, # 7 p. 1075 - 1083
反应条件
1: 71 percent / 24 h / Ambient temperature
2: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature
3: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
4: HBr / trifluoroacetic acid
5: 70 percent / acetonitrile / 24 h
6: 88 percent / methanol; diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
