1-(苯基甲基)-4,4-哌啶二乙酸 4,4-二乙酯合成路线 （共 6 条）
反应条件
1: 1-Phenylmethyl-piperidin-4-one; cyanoacetic acid ethyl ester With ammonia in methanol T=0°C; 120 h; 2: With sulfuric acid; water T=100°C; 48 h; Heating / reflux; 3: ethanol With sulfuric acid 24 h; Heating / reflux;
参考文献
Kyorin Pharmaceutical Co., Ltd.; Nisshin Pharma Inc.
Patent: EP1443046 A1, 2004 ;
Location in patent: Page 186-187 ;
EP 1443046 A1
反应条件
in ethanol; sulfuric acid; ammonia; water; sodium carbonate
参考文献
Merck and Company, Inc.
Patent: US5776930 A1, 1998 ;
反应条件
1: 65.5 percent / NH3 / ethanol / 96 h / 0 - 2 °C 2: aq. H2SO4 / 8.5 h / Heating 3: H2SO4 / 14 h / Heating View Scheme
参考文献
Karl Thomae GmbH
Patent: US5681841 A1, 1997 ;
反应条件
1: aq. H2SO4 / 8.5 h / Heating 2: H2SO4 / 14 h / Heating View Scheme
参考文献
Leonardi, Amedeo; Barlocco, Daniela; Montesano, Federica; Cignarella, Giorgio; Motta, Gianni; Testa, Rodolfo; Poggesi, Elena; Seeber, Michele; De Benedetti, Pier G.; Fanelli, Francesca
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1900 - 1918
反应条件
sulfuric acid 14 h; Heating;
参考文献
Leonardi, Amedeo; Barlocco, Daniela; Montesano, Federica; Cignarella, Giorgio; Motta, Gianni; Testa, Rodolfo; Poggesi, Elena; Seeber, Michele; De Benedetti, Pier G.; Fanelli, Francesca
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1900 - 1918
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
GRUENENTHAL GmbH
Patent: US2010/113417 A1, 2010 ;
Location in patent: Page/Page column 37 ;
