Dowex 50W-X8; water in tetrahydrofuran Heating;

<b>Multi-step reaction with 4 steps<br /> </b>1: aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / Ambient temperature<br />2: 95 percent / Dowex 50W-X₈ resin, water / methanol / 16 h / Ambient temperature; further catalysts and solvents<br />3: 78 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 &deg;C<br />4: 95 percent / H₂, sodium acetate / Pd-C / methanol / 10 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: H₂ / Pd-C / ethyl acetate / 6 h<br />2: aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / Ambient temperature<br />3: 95 percent / Dowex 50W-X₈ resin, water / methanol / 16 h / Ambient temperature; further catalysts and solvents<br />4: 78 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 &deg;C<br />5: 95 percent / H₂, sodium acetate / Pd-C / methanol / 10 h<br /> <br /> &nbsp;