1-(3-甲氧基苯基)哌嗪合成路线 （共 14 条）
反应条件
1: piperazine With [2,2']bipyridinyl; nickel diacetate; sodium hydride; 1,1-dimethylpropan-1-ol in tetrahydrofuran T=65°C; 2 h; 2: 1-chloro-3-methoxy-benzene With styrene in tetrahydrofuran T=65°C; 6 h;
参考文献
Tetrahedron, , vol. 58, # 34 p. 6913 - 6924
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: 1-chloro-3-methoxy-benzene With styrene in tetrahydrofuran Arylation; 6 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2881 - 2884
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; sodium t-butanolate in toluene T=100°C; 4-fold excess of piperazine;
参考文献
Zhao, Shu-Hai; Miller, Aubry K.; Berger, Jacob; Flippin, Lee A.
Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4463 - 4466
反应条件
tris-(dibenzylideneacetone)dipalladium(0) in o-xylene; water
反应条件
piperazine; sodium t-butanolate; [Pd2(dba)2]; RF-PPh3 in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620
反应条件
1.) DMSO, 25 deg C, 0.7 h, in dark, 2.) DMSO, 80 deg C, 3 h, hν; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 37, # 47 p. 8487 - 8488
参考文献
Karl Thomae
Patent: US5994356 A1, 1999 ;
