sodium hydroxide; methanesulfonyl chloride; triethylamine 1.) CH2Cl2, MeOH, 2.) H2O, reflux.; Yield given. Multistep reaction;

1: 97 percent / Et3N / CH2Cl2 / 12 h / Ambient temperature 2: 1.) MsCl, Et3N, 2.) NaOH / 1.) CH2Cl2, MeOH, 2.) H2O, reflux. View Scheme

sodium hydroxide in methanol 3 h; Heating; Yield given;

1: 97 percent / Et3N / CH2Cl2 / 12 h / Ambient temperature 2: 1.) MsCl, Et3N, 2.) NaOH / 1.) CH2Cl2, MeOH, 2.) H2O, reflux. View Scheme

1: lithium aluminium tetrahydride / tetrahydrofuran / 17.25 h / 0 °C / |Inert atmosphere; |Reflux 2: triethylamine / dichloromethane / 2 h / 0 - 20 °C 3: triethylamine; 4-(N,N-dimethlyamino)pyridine; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C View Scheme