1-三乙基硅烷-4-三乙基硅氧烷-1-丁炔合成路线 （共 5 条）
反应条件
1: ethynylmethyl carbinol With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: triethylsilyl chloride in tetrahydrofuran; hexane T=20°C; 24 h;
参考文献
Heterocycles, , vol. 57, # 3 p. 465 - 476
反应条件
1: With n-butyllithium in tetrahydrofuran T=-40 - -20°C; 2 h; Inert atmosphere; 2: With triethylsilyl chloride in tetrahydrofuran T=-40 - 20°C; Inert atmosphere;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 13 p. 2055 - 2062
反应条件
1: With 2 mol Pd/C; sodium carbonate in N,N-dimethyl-formamide T=120°C; Larock heteroannulation; 18 h; Inert atmosphere; 2: With hydrogenchloride in water regioselective reaction;
参考文献
Batail, Nelly; Dufaud, Veronique; Djakovitch, Laurent
Tetrahedron Letters, 2011 , vol. 52, # 16 p. 1916 - 1918
反应条件
hydrogenchloride; palladium diacetate; sodium carbonate 1.) DMF, 100 deg C; 2.) MeOH; Yield given. Multistep reaction;
参考文献
Chen, Cheng-Yi; Lieberman, David R.; Larsen, Robert D.; Reamer, Robert A.; Verhoeven, Thomas R.; Reider, Paul J.; Cottrell, Ian F.; Houghton, Peter G.
Tetrahedron Letters, 1994 , vol. 35, # 38 p. 6981 - 6984
反应条件
hydrogenchloride; water in methanol T=20°C; 4 h;
参考文献
GRUNENTHAL GMBH
Patent: US2009/156593 A1, 2009 ;
Location in patent: Page/Page column 17 ;
