4-(三乙基甲硅烷基)-3-硫酸丁基卡因-1-醇合成路线 （共 3 条）
反应条件
hydrogenchloride; water in methanol T=20°C; 4 h;
参考文献
GRUNENTHAL GMBH
Patent: US2009/156593 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
1: ethynylmethyl carbinol With n-butyllithium in tetrahydrofuran; toluene T=-68°C; 1 h; 2: triethylsilyl chloride in tetrahydrofuran; toluene T=-68 - 20°C; 20 h; 3: With hydrogenchloride in tetrahydrofuran; water; toluene 48 h;
参考文献
Wennekes, Tom; Van Den Berg, Richard J. B. H. N.; Boltje, Thomas J.; Donker-Koopman, Wilma E.; Kuijper, Bastiaan; Van Der Marel, Gijsbert A.; Strijland, Anneke; Verhagen, Carlo P.; Aerts, Johannes M. F. G.; Overkleeft, Herman S.
European Journal of Organic Chemistry, 2010 , # 7 p. 1258 - 1283
反应条件
1: BuLi 2: aq. HCl / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 38 p. 6981 - 6984
