amberlyst-15; 4 A molecular sieve in acetonitrile T=20°C; 3.5 h;

1: With E. coli T=30°C; Baeyer-Villiger oxidation; 36 h; Enzymatic reaction; 2: With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal in methanol; water 5 h; Title compound not separated from byproducts;

calcium tetrakis(pentafluorophenyl)borate undecahydrate; dihydrogen peroxide; oxalic acid in 1,2-dichloro-ethane T=50°C; Baeyer-Villiger Ketone Oxidation; 6 h;

1: 93 percent / MCPBA / CH2Cl2 / 6 h 2: 49 percent / (R,R)-(salen)Co(OAc) / H2O / 30 h / 20 °C 3: Amberlyst-15; 4 Angstroem molecular sieves / acetonitrile / 3.5 h / 20 °C View Scheme

1: aq. LiOH / H2O; tetrahydrofuran / 1.5 h / 20 °C / pH 4 2: 231 mg / CSA / CH2Cl2 / 0.33 h / -5 °C View Scheme

1: 1.) AgNO3, NaOH; 2.) satd. aq. oxalic acid / 1.) 5 deg C, 1 h; 2.) pH=3.7 2: amberlyst 15, 4A molecular sieves / 6 h / 20 °C View Scheme