(4-噻吩-3-苯基)甲醇合成路线 （共 11 条）
反应条件
manganese(IV) oxide in chloroform 1 h; Heating;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; IIT - ISTITUTO ITALIANO DI TECNOLOGIA; UNIVERSITY DEGLI STUDI DI URBINO; UNIVERSITA DEGLI STUDI DI PARMA; PIOMELLI, Daniele; BANDIERA, Tiziano; MOR, Marco; TARZIA, Giorgio; BERTOZZI, Fabio; PONZANO, Stefano
Patent: WO2013/78430 A1, 2013 ;
Location in patent: Paragraph 0357 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=25°C; 0.75 h;
参考文献
Naudin, Eric; Ho, Hoang Anh; Bonin, Marc-Andre; Breau, Livain; Belanger, Daniel
Macromolecules, 2002 , vol. 35, # 13 p. 4983 - 4987
反应条件
tetrakis(triphenylphosphine) palladium(0) in xylene
T=140°C; 1 h;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
aq. NaOH in tetrahydrofuran; diethyl ether; water
参考文献
Merck and Co., Inc.
Patent: US5939557 A1, 1999 ;
反应条件
potassium hydroxide in ethanol
5 h; Heating;
参考文献
Marwah, A. K.; Marwah, Padma; Rao, G. Shankar; Trivedi, B. S.; Rao, B. E.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 3 p. 197 - 200
反应条件
1.1: 89 percent / imidazole / CH2Cl2 / 0.75 h
2.1: magnesium / tetrahydrofuran / 2 h / Heating
2.2: 67 percent Turnov. / NiCl2(dppe) / tetrahydrofuran / 3 h / Heating
3.1: 94 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 0.75 h / 25 °C
View Scheme
参考文献
Naudin, Eric; Ho, Hoang Anh; Bonin, Marc-Andre; Breau, Livain; Belanger, Daniel
Macromolecules, 2002 , vol. 35, # 13 p. 4983 - 4987
反应条件
1.1: magnesium / tetrahydrofuran / 2 h / Heating
1.2: 67 percent Turnov. / NiCl2(dppe) / tetrahydrofuran / 3 h / Heating
2.1: 94 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 0.75 h / 25 °C
View Scheme
参考文献
Naudin, Eric; Ho, Hoang Anh; Bonin, Marc-Andre; Breau, Livain; Belanger, Daniel
Macromolecules, 2002 , vol. 35, # 13 p. 4983 - 4987
反应条件
1: 85.38 percent / N-bromosuccinimide, dibenzoylperoxide / CCl4 / 1 h / Heating
2: 79.74 percent / 18-crown-6 / acetic acid / 8 h / Heating
3: 88.5 percent / aq. KOH / ethanol / 5 h / Heating
View Scheme
参考文献
Marwah, A. K.; Marwah, Padma; Rao, G. Shankar; Trivedi, B. S.; Rao, B. E.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 3 p. 197 - 200
反应条件
1: 79.74 percent / 18-crown-6 / acetic acid / 8 h / Heating
2: 88.5 percent / aq. KOH / ethanol / 5 h / Heating
View Scheme
参考文献
Marwah, A. K.; Marwah, Padma; Rao, G. Shankar; Trivedi, B. S.; Rao, B. E.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 3 p. 197 - 200
