2-氨基-5-甲基吡啶合成路线 （共 125 条）
反应条件
in butan-1-ol
Heating;
参考文献
Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118
反应条件
1: sodium nitrite; aqueous tetrafluoroboric acid / Diazotization
2: KMnO4; H2O
3: SOCl2 / Behandeln des Reaktionsprodukts mit NH3 in Benzol
View Scheme
参考文献
Minor et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1125
反应条件
1: 85 percent / HBr, Br2
2: 1.) n-BuLi, Bu3SnCl / 2.) Pd(PPh3)4 / 1. -78 deg C; 2.) Stille coupling
3: 99 percent / LDA / tetrahydrofuran / 0.02 h / -78 °C
4: 99 percent / C2Br2F4, CsF / dimethylformamide / 2 h / 25 °C
View Scheme
参考文献
Schubert, Ulrich S.; Eschbaumer, Christian; Hochwimmer, Georg
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8643 - 8644
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 18 h / Molecular sieve; Inert atmosphere; Reflux
2: tetrahydrofuran / -78 - 20 °C / Molecular sieve; Inert atmosphere
3: [copperl(II)(1,1,1,5,5,5-hexafluoroacetylacetonate)2] monohydrate; oxygen / N,N-dimethyl-formamide / 14 h / 105 °C
View Scheme
参考文献
Wang, Honggen; Wang, Yong; Liang, Dongdong; Liu, Lanying; Zhang, Jiancun; Zhu, Qiang
Angewandte Chemie - International Edition, 2011 , vol. 50, # 25 p. 5678 - 5681
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 18 h / -78 °C / Molecular sieve; Inert atmosphere; Reflux
2: tetrahydrofuran / -78 - 20 °C / Molecular sieve; Inert atmosphere
3: [copperl(II)(1,1,1,5,5,5-hexafluoroacetylacetonate)2] monohydrate; oxygen / N,N-dimethyl-formamide / 15 h / 105 °C
View Scheme
参考文献
Wang, Honggen; Wang, Yong; Liang, Dongdong; Liu, Lanying; Zhang, Jiancun; Zhu, Qiang
Angewandte Chemie - International Edition, 2011 , vol. 50, # 25 p. 5678 - 5681
反应条件
sulfuric acid; nitric acid
参考文献
Hall; VanderWerf
Journal of the American Chemical Society, 1951 , vol. 73, p. 4466
反应条件
1: acetic acid
2: aqueous KMnO4
3: methanol; HCl
4: acetic acid
5: concentrated aqueous NH3
View Scheme
参考文献
Ferrari
Bollettino Chimico Farmaceutico, 1957 , vol. 96, p. 542,543
反应条件
sodium hydrogencarbonate
参考文献
Maury, G.; Pigiere, C.
Tetrahedron, 1981 , vol. 37, p. 83 - 90
反应条件
1: 2 h / 80 °C
2: m-chloroperbenzoic acid / CH2Cl2 / 20 °C
View Scheme
参考文献
Clarke, Matthew L.; Fuentes, Jose A.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 6 p. 930 - 933
反应条件
1: pyridine
2: acetic acid; aqueous H2O2
3: concentrated aqueous HCl
View Scheme
参考文献
Katritzky
Journal of the Chemical Society, 1957 , p. 4385
