2-氨基-5-甲基吡啶合成路线 （共 125 条）
反应条件
1.1: propan-2-ol / Heating
1.2: 80 percent / hydroxylamine hydrochloride / propan-2-ol / 50 °C
2.1: 75 percent / trifluoroacetic anhydride / tetrahydrofuran / 20 °C
View Scheme
参考文献
Huntsman, Elliott; Balsells, Jaume
European Journal of Organic Chemistry, 2005 , # 17 p. 3761 - 3765
反应条件
1.1: 91 percent / Br2; aq. HBr; NaNO2 / 0 °C
2.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C
2.2: selenium / tetrahydrofuran / -78 - 20 °C
2.3: 70 percent / air / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Bhasin; Venugopalan; Singh
Phosphorus, Sulfur and Silicon and the Related Elements, 2002 , vol. 177, # 11 p. 2579 - 2587
反应条件
1: hydrogen bromide; dihydrogen peroxide / 2 - 4 h / 70 °C
2: glycerol / 0.25 - 0.33 h / Microwave irradiation
View Scheme
参考文献
Kaloyanova, Stefka; Crnolatac, Ivo; Lesev, Nedyalko; Piantanida, Ivo; Deligeorgiev, Todor
Dyes and Pigments, 2012 , vol. 92, # 3 p. 1184 - 1191
参考文献
Lavielle, Gilbert; Dubuffet, Thierry; Muller, Olivier; Millan, Mark; Dekeyne, Anne; Brocco, Mauricette
Patent: US2003/87916 A1, 2003 ;
参考文献
Sudha, L. V.; Sathyanarayana, D. N.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1984 , vol. 40, # 8 p. 751 - 756
参考文献
Addison, Anthony W.; Burke, Philip J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 803 - 805
反应条件
copper(l) iodide in N,N-dimethyl-formamide
T=80°C; 24 h; Green chemistry;
参考文献
Yang, Sizhuo; Yan, Hao; Ren, Xiaoyu; Shi, Xiaokang; Li, Jian; Wang, Yuling; Huang, Guosheng
Tetrahedron, 2013 , vol. 69, # 31 p. 6431 - 6435
反应条件
triethylamine in 1,2-dichloro-ethane
T=60°C; 3 h;
参考文献
Robert-Piessard, Sylvie; Le Baut, Guillaume; Courant, Jacqueline; Brion, Jean-Daniel; Sparfel, Louis; et al.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 9 - 19
反应条件
0.0583333 h; microwave irradiation;
参考文献
Charris; Dominguez; Lopez
Heterocyclic Communications, 2001 , vol. 7, # 3 p. 233 - 236
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=150°C; 0.333333 h; Microwave (CEM);
参考文献
Amgen Inc.
Patent: WO2006/116713 A1, 2006 ;
Location in patent: Page/Page column 208 ;
WO 2006/116713 A1
