2-氨基-5-甲基吡啶合成路线 （共 125 条）
反应条件
2: diphenyl ether
View Scheme
参考文献
Lappin
Journal of the American Chemical Society, 1948 , vol. 70, p. 3348
反应条件
in ethanol
1 h; Heating;
参考文献
Valdes-Martinez, Jesus; Hernandez-Ortega, Simon; Espinosa-Perez, Georgina; Presto, Carmina A; Hermetet, Anne K; Haslow, Kristin D; Ackerman, Lily J; Szczepura, Lisa F; Goldberg, Karen I; Kaminsky, Werner; West, Douglas X
Journal of Molecular Structure, 2002 , vol. 608, # 1 p. 77 - 87
反应条件
1.1: 48percent HBr; Br2 / 1.5 h / -20 °C
1.2: aq. NaNO2 / -20 - 15 °C
1.3: 89 percent / aq. NaOH / -10 - 20 °C
2.1: 64 percent / Pd(PPh3)4 / toluene / 48 h / Heating
View Scheme
参考文献
Schubert, Ulrich S.; Eschbaumer, Christian; Heller, Marcel
Organic Letters, 2000 , vol. 2, # 21 p. 3373 - 3376
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 16 h; Inert atmosphere;
参考文献
AVENTIS PHARMA DEUTSCHLAND GMBH
Patent: WO2005/105781 A1, 2005 ;
Location in patent: Page/Page column 49 ;
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran
T=20°C; 70 h;
2: With trifluoroacetic acid in tetrahydrofuran; dichloromethane
T=20°C; 18 h;
参考文献
Kawamura, Koji; Miyoshi, Keita; Kobayashi, Emi
Patent: US2012/142932 A1, 2012 ;
Location in patent: Page/Page column 5 ;
