2-氨基-5-甲基吡啶合成路线 （共 125 条）
反应条件
1: 1.) NaNO2, 2.) 48percent aq. HBF4 2: 45 percent / KMnO4 / H2O / 4.5 h / 100 °C View Scheme
参考文献
Al Jammaz; Al-Otaibi; Okarvi; Amartey
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 6 p. 312 - 317
参考文献
Frimannsson, Daniel O.; McCabe, Thomas; Schmitt, Wolfgang; Lawler, Mark; Gunnlaugsson, Thorfinnur
Supramolecular Chemistry, 2010 , vol. 22, # 9 p. 483 - 490
参考文献
Sankyo Company, Limited
Patent: US5541317 A1, 1996 ;
反应条件
1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: copper 3: KMnO4; H2O View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 2574,2576
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 18 h / Molecular sieve; Inert atmosphere; Reflux 2: tetrahydrofuran / -78 - 20 °C / Molecular sieve; Inert atmosphere 3: [copperl(II)(1,1,1,5,5,5-hexafluoroacetylacetonate)2] monohydrate; oxygen / N,N-dimethyl-formamide / 16 h / 105 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 25 p. 5678 - 5681
反应条件
0.00833333 h; Microwave irradiation;
参考文献
Smith, Robert B.; Faki, Hajira; Leslie, Ray
Synthetic Communications, 2011 , vol. 41, # 10 p. 1492 - 1499
反应条件
1: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization 2: peroxyacetic acid; acetic acid View Scheme
参考文献
Brown
Journal of the American Chemical Society, 1957 , vol. 79, p. 3565
反应条件
1.1: NaNO2 / acidic aq. solution 1.2: Br2; HBr 2.1: BuLi / tetrahydrofuran / -78 °C 2.2: 95 percent / tetrahydrofuran 3.1: 65 percent / Pd(PPh3)4 / toluene / Heating View Scheme
参考文献
Gavina, Pablo; Tatay, Sergio
Tetrahedron Letters, 2006 , vol. 47, # 20 p. 3471 - 3473
反应条件
1: acetic acid 2: aqueous KMnO4 3: methanol; HCl 4: acetic acid View Scheme
参考文献
Ferrari
Bollettino Chimico Farmaceutico, 1957 , vol. 96, p. 542,543
反应条件
1: 82 percent / methyl nitrite, aq. HCl / 15 °C 2: 90 percent / CS(NH2)2, aq. HCl / 20 h / Heating View Scheme
参考文献
Neidhart, Werner; Breu, Volker; Burri, Kaspar; Clozel, Martine; Hirth, Georges; Klinkhammer, Uwe; Giller, Thomas; Ramuz, Henri
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2223 - 2228
