3-氯-1H-吡唑并[3,4-b]喹噁啉合成路线 （共 6 条）
反应条件
tri-chlorocyanuric acid in N,N-dimethyl-formamide T=80°C; 0.166667 h;
参考文献
Heydenreich, Matthias; Koch, Andreas; Sarodnick, Gerhard; Kleinpeter, Erich
Tetrahedron, 2005 , vol. 61, # 9 p. 2373 - 2385
反应条件
hydrogenchloride; sodium nitrite 1.) 0 deg C, 2.) water, 60 min; Yield given. Multistep reaction;
参考文献
Ortega, Miguel A.; Montoya, Maria E.; Zarranz, Belen; Jaso, Andres; Aldana, Ignacio; Leclerc, Sophie; Meijer, Laurent; Monge, Antonio
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2177 - 2184
反应条件
1: 2.) triethylamine / 1.) DMF, o deg C, 2.) DMF, 10 deg C, 4 h 2: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h 3: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h 4: 90 percent / hydrazine hydrate / 1 h / Heating 5: 1.) 6N HCl, 2.) sodium nitrite / 1.) 0 deg C, 2.) water, 60 min View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 90 percent / hydrazine hydrate / 1 h / Heating 2: 1.) 6N HCl, 2.) sodium nitrite / 1.) 0 deg C, 2.) water, 60 min View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h 2: 90 percent / hydrazine hydrate / 1 h / Heating 3: 1.) 6N HCl, 2.) sodium nitrite / 1.) 0 deg C, 2.) water, 60 min View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h 2: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h 3: 90 percent / hydrazine hydrate / 1 h / Heating 4: 1.) 6N HCl, 2.) sodium nitrite / 1.) 0 deg C, 2.) water, 60 min View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
