5-(3-溴苯基)-3-甲基-1,2,4-恶二唑合成路线 （共 2 条）
反应条件
1: acetamide oxime With sodium hydride in tetrahydrofuran T=20 - 50°C; 1 h; 2: (3-bromophenyl)acetic acid methyl ester in tetrahydrofuran 1 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/40192 A1, 2006 ;
Location in patent: Page/Page column 38 ;
WO 2006/040192 A1
反应条件
1-propanephosphonic acid cyclic anhydride; triethylamine in ethyl acetate T=80°C; 3 h;
参考文献
MERCK SHARP and DOHME CORP.; GILBERT, Eric, J.; CUMMING, Jared, N.; STAMFORD, Andrew, W.; YU, Younong; SCOTT, Jack, D.; ISERLOH, Ulrich; WANG, Lingyan; CALDWELL, John, P.
Patent: WO2014/62553 A1, 2014 ;
Location in patent: Page/Page column 56 ;
